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Dissertações

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Rapid evolution of AlpA adhesin of Helicobacter pylori in Colombia

In order to survive, H. pylori must adheres the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example AlpA.

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H. pylori genome/methylome project in Japan

We have decoded genomes/methylomes of over 150 H. pylori strains by Single-Molecule Real-Time (SMRT) sequencing in Pacbio machines in collaboration with National Institute of Genetics, National Institute for Basic Biology, and Pacificbioscience of California.

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Helicobacter pylori infection induces abnormal expression of proangiogenic genes and microRNAs in gastric cell lines

H. pylori infection can induce angiogenesis in the pre-neoplastic cascade of events that culminates in gastric cancer, which may have important functional implications for the etiology of this disease.

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Isolation frequency of H. pylori and non-H. pylori bacteria from gastric biopsies of patients with chronic gastritis, gastric ulcer and gastric cancer

Recent studies show that, in addition to Helicobacter pylori, other bacterial species such as Proteus mirabilis, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter cloacae and Staphylococcus aureus are found in the gastric mucosa, either in co-infection with H. pylori or not.

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A LONGITUDINAL STUDY OF CELL-FREE DNA OF REPRIMO METHYLATED, PEPSINOGENS AND HELICOBACTER PYLORI IN PLASMA AS A NON-INVASIVE RISK-ASSESSMENT FOR OLGA STAGING

Gastric cancer (GC) is the fifth most common cause of cancer death worldwide with approximately one million cases diagnosed annually.

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Helicobacter pylori Genome Project (HpGP)

Although Helicobacter pylori is causally associated with gastric cancer, <1% of infected individuals develop this malignancy. H. pylori infection induces gastritis that variably progresses to atrophy, intestinal metaplasia (IM), dysplasia and cancer.